Her first mission was to kill Koga's wolf tribe, and make it appear as if it were Inuyasha's fault, which Koga temporarily believed. When she failed due to Inuyasha's Wind Scar, Naraku admitted to manipulating her, and she responded by attacking him with her folding fan. He then reminds her that he literally holds her heart in his hand, squeezing it for emphasis. From her first mission onward, she continues to fight Inuyasha and his allies while feigning loyalty to Naraku.

Kagura later shows an interest in Sesshomaru, believing him powerful enough to destroy Naraku. When they first meet, Sesshomaru coldly dismisses her, telling her that if she wants Naraku dead she should deal with him herself. Some time after, she abducts Rin in the hopes of luring Sesshomaru to Naraku's castle, and it works. When he cuts himself free of Naraku's tentacles, Kagura concludes that he will be the one to destroy Naraku.

Following the Band of Seven arc, Kagura is charged with taking care of Naraku's latest incarnation, The Infant, a task which she hated. After Naraku learns of the Border to the Afterlife, The Infant searches for the border by reading the minds of monks and priests, whom Kagura promptly slays afterwards. She was pleased when Shinsen, a particularly powerful monk, was able to split The Infant in half, apparently killing both. However, Kagura was quickly proven wrong, when the right half of The Infant matured, creating Hakudoshi. She was then charged with working with the child.

Hakudoshi took delight in ordering Kagura around, and she soon began to realize that there was something especially important about The Infant, who was entrusted to Kanna, whom Naraku trusted more. When Hakudoshi sent Kagura to "test" the gate to the underworld guarded by Gozu and Mezu, she discovered that, when the gate opened, it turned all nearby living creatures to stone. Furious, she returned to Hakudoshi, attempting to cut him in half with her folding fan; immediately after, Naraku squeezed her heart. It was at this point that Kagura became more active in her quest for freedom. She also came to the realization that The Infant was Naraku's heart, and that by killing him, her master would be destroyed as well.

At this point, Kagura begins to visit Sesshomaru more frequently, eventually leading Rin to speculate that she has a romantic interest in the daiyokai. She begins looking after Kohaku, and protects him as his memories begin to return. During the Final Act, Hakudoshi creates his own plan to betray Naraku, and tries to enlist Kagura's help, imploring her to free an imprisoned Goryomaru, a demon-slaying monk who had been presumably killed. Kagura had been charged with guarding him, and correctly assumed that Hakudoshi had traitorous intentions. When he and his demonic construct Moryomaru began targeting Kohaku for the jewel shard in his neck, Kagura actively protected him, allowing him to escape. She assists her long-time enemy Inuyasha by telling him that The Infant is inside Moryomaru, and after Hakudoshi is slain by Miroku, Kagome offers Kagura to travel with them, which she declines because they had been enemies for too long.

Naraku then returns Kagura's heart to her, granting her "freedom", although he also injects her with his miasma. As she is dying in a field of flowers, she wonders if she will die alone, but is then visited by Sesshomaru. She proclaims that she wanted to see him one last time before vanishing into thin air, becoming the wind..

Kagura has awakened from Death anew, resurrected with out any real known reason or purpose. Because she is still new to the world, her powers have not fully developed leaving her weak and vulnerable. The only thing she knows for sure is that there is a darkness inside her, a hunger for flesh and blood. The Spider is her symbol according to Sesshomaru and she is also an Elemental Yokai meaning she still retains the spider scar on her back that when she transforms, causes spider legs to tear from her back and her clothing to be destroyed leaving her in a rather seductive outfit with black clawlike nails. She has the power of Aranic Charm which causes men and women who fall for her to be blinded by her spider like features. She then lures them in and feeds on them. At the time she is fighting that side of herself with no ability to control it.

She travels during the day and seeks shelter at night as she fears the dangers that come at night fall, being used to demons and the like she will either find a cave or a tree to stay in until daybreak and begin to travel again. At the moment she is traveling with Lord Sessohamru and his companions, finding at least some comfort in being with someone she knows from her past life.