After the meteor shower of 2005, Lois went to look for the Kents at the barn and found them both alive, but Martha was seriously injured. She helped Jonathan take her to the hospital where she was assaulted by Kryptonians Nam-Ek and Aethyr. They let her go when Lana Lang diverted their attention by telling them what they wanted to know. Lois then continued her original plan to leave with General Lane in search of her sister. Soon afterward, Lois returned to Smallville and moved back into Kent Farm and got her old job back at the Talon, much to the annoyance of Clark. At Crater Lake, Lois hit her head while diving and almost drowned. Clark went in to save her, but was beat by an another swimmer, Arthur Curry. They connected and kissed, but was caught by Clark walking in on them. Clark became extremely rude to Arthur, and Lois told Clark to back off, thinking that he's jealous of Arthur. Clark and Lois eventually made up and soon afterward Arthur Curry left town. Lois was very disappointed, but Clark told her that she'll find someone more special than Arthur someday. Lois and Chloe found themselves in the middle of a murder investigation after receiving a call from an exotic dancer from the Windgate Club. Lois is forced into an uncomfortable position when they get caught by being passed off as a dancer, and is forced to perform in order to continue the investigation. She is almost taken out of the country until she was saved unknowingly by Clark, She thanks Clark for his efforts in saving her and they part as friends. Shortly after, Lois moved out of the Kent's and into the apartment above the Talon and started to spend more time with Chloe in the nights at the Daily Planet. During Jonathan and Lex's Senate race, Lois confronted Lex and suggested he bow out before someone dug up incriminating information on him. Lex was unconcerned, which fueled her passion even more. She convinced Chloe to help her dig up information on Lex that would make him lose the race. They attempted to investigate Warehouse 15, but were thwarted by security. Lois was disappointed to come up empty-handed, and Chloe suggested she become a reporter. Lois commented that she would never be able to stand all of the unanswered questions. Lois was wined and dined by the wealthy Graham Garrett after Clark saved his life and he met her at Clark's house. He began to lavish her with expensive and exotic dates and Lois started to feel more attracted to him. Without her knowing, Garret began to spy on her and after Chloe revealed Graham to be a hired hit-man and a killer, Lois talked to Martha about why she always attracted to bad boys, but Martha assured her that she had similar experiences at Lois' age, and tells Lois that the reason they date the wrong people is so that they can recognize the right person. On Clark's birthday, Lois made him an irregular blue rum cake and gave him a journal, so that he would hopefully find some way to release all the feelings he kept bottled up about Lana and maybe move on with his life. Later, Lois met Lana at the Talon and realized that she was in a relationship with Lex and offered an ear and had a three hour conversation with Lana about the status of her relationship with Lex. When Clark was depressed because of the developing relationship between Lex and Lana, Lois tried to reassure him by reminding him he will find someone someday that may not be Lana. When Martha and Lois were scheduled to attend a conference in Washington D.C., their flight was cancelled and then Lionel offered them the LuthorCorp jet and Martha accepted. When they started noticing certain surroundings that shouldn't be there like mountains in the distance, Lois tries to get a hold of the pilot to find out what was going on, but he didn't respond as the pilot turned out to be Brainiac leading them to their demise. She tried to get the door open and starts to realize that he turned the oxygen off which made Martha pass out but Lois was able to get the emergency oxygen tank out, but she soon passed out as well before she could reach for them and actually use them. Lois and Martha's plane crashed near the Fortress of Solitude. She awakened for a time while there, but later told at the hospital that she only vaguely remembered the structure and thought it was heaven. Clark told her that maybe she hallucinated, but she insisted that it was real. Clark expressed that he was glad she was okay and spontaneously hold her hand, making Lois uncomfortable and she awkwardly pulled away. Lois was jogging when the Kents' barn door came crashing out of the sky and land close to her. She was determined to discover what made it fly off the barn and relentlessly investigated, despite Chloe's attempts to get her to drop the subject. She wrote an article for the Daily Planet, but Chloe discouraged her, trying to protect Clark, and seemingly doubting it was good enough to be published. Undeterred, she successfully shopped her story to the Metropolis Inquisitor and received her first byline and then she began moonlighting for the Inquisitor. Lois was close to accepting a job when she met Oliver Queen and accidentally insulted him, thinking he was the messenger boy for Queen Industries. She was sternly chastised by Martha and went to his loft to apologize. He accepted, but only if she attended Lex Luthor's costume ball as his date. At the end of the night, she denied Oliver a kiss, saying he would have to earn it. Enamored, Oliver continued to woo her, and they began a relationship. When Oliver met Clark, he commented on Clark's "feelings" for Lois, which both Lois and Clark quickly brushed off. While attending a fund-raiser with Oliver, Lois witnessed the Green Arrow stealing a rare diamond necklace off Martha's neck and vowed to find the man behind the mask. She wrote an article about him, dubbing him the "Green Arrow Bandit." Later, she was captured by crooks who also wanted to know who the Green Arrow was and was rescued by the Green Arrow himself. Lois blamed him for her harrowing experience and was about to unmask him until Clark ensured Oliver a quick escape route. Later, she told Oliver that she would not give up until she unmasked Green Arrow. She told him that she considers the Green Arrow dangerous, making Oliver concerned and worried. Lois confronted Senator Burke outside an alley and witnessed his murder by the invisible Wes Keenan. When he showed himself, Lois was shocked to recognize him as a childhood friend. The Kents suggested Lois stay on the farm for protection from Wes, but he located her anyway. However, their shared history caused Wes to disobey his orders to kill her and he apprehended her instead. With Lois' help, Wes was able to fend off his mind control long enough to explain what happened to him. Clark and Chloe tracked them down to an old military base and Clark was, able to save Wes from killing Lois, unseen. Wes died in Lois' arms, stating he'd rather be dead than used as a weapon, and repeating a string of numbers. Wes' death motivated Lois to get to the bottom of Project Ares, so she studied the numbers that Wes died repeating, until she realized they were latitude and longitude coordinates. She tracked it down to Reeves Dam, but when she got there, Lois was confronted by a guard who stabbed her in the stomach. Lois was able to call Chloe for help before she passed out. Chloe found Lois near death from blood loss and began to cry. Mysteriously, her tears healed Lois' stab wound and she recovered, horrified to find that Chloe was the one near death, and the dam crumbling, trapping them inside.

In the collapsed dam, Lois encountered Philipe Lamont, the boy previously possessed by Bizarro while trying to escape. Clark heard her calling for help and took all three to the hospital where the doctors tried to revive Chloe. Restless, Lois instructed Clark to stay with Chloe while she went to the Luthor Mansion to search for clues that pointed to Lex's involvement with the project. There, she ran into Bizarro, who had taken Clark's form. Mistaking him for Clark, she was angered when he made a pass at her and slapped him across his face. Later, Lois deduced that "Clark"'s odd behavior was due to his grief over Lana Lang's reported death, and sincerely offered her condolences. Lois was determined to investigate the dam and after discovered a red spaceship with Clark, she took a picture with her cell phone but it was crushed by a blonde woman, who knocked Lois out. Lois visited Chloe at work at Daily Planet and tried to convince her that she'd seen a UFO but Chloe refused the idea. Then the new editor of the newspaper offered Lois a job if she could write a good story about her spaceship. Although Lois wrote her story, but had no photograph to accompany it, so Grant declared that he would not publish it, but would still hire her at the Daily Planet. Lois became Grant's ingenue, getting sent on prestigious and exciting out-of-town assignments. However, she was still interested in proving Lex Luthor's role in the Reeves Dam project. Against Grant's assignments, she chose to investigate the purchase of land close to the dam, authorized by someone with the initials "LL". She sneaked into LuthorCorp but was quickly caught and thrown out by Lex Luthor. Grant asked Lois to accompany him to a social function, but she turned him down. However, Lois and Grant became increasingly close. After Lana went in catatonic state, Lois tried to support Clark and help him with Lana's condition as he helped her when she had to break things off with Oliver. Lois suggested Clark apply for an internship at the Daily Planet, saying that he's meant for more than farm work. He refuses the offer and tells her that he can never work for Lex Luthor. Then she asked him about his and Lex’s past friendship and how that lasted for so long because they had nothing in common with one another, but Clark just said that sometimes people don't turn out to be who you expect. Lois then began digging into Lex's excursions to the Arctic Circle, but Jimmy was set up by Lex to throw her off the track. She believed Jimmy, but was still skeptical about Lex's activities. Lois arrived at the Kent house just as Clark finished viewing a break-up video left for him by Lana Lang. She offered support by giving a devastated Clark a comforting hug.

Lois snuck into the Luthor Mansion, dressed as a maid, looking for evidence of her cousin's disappearance, but was immediately recognized by Lex's assistant, Tess Mercer, but not before stealing a thumb drive containing possible information about Chloe. She learned that Chloe was being held in a secret base in Montana and set about finding her. She unexpectedly ran into Clark Kent, who was present with Oliver Queen, also on a mission to save Chloe. They located Chloe, but Lois was tasered unconscious. Back at work, she was working late when Clark unexpectedly arrived to tell her that he had taken her advice and decided to get a job at the Daily Planet. On Clark´s first day at the Planet, Lois helped him by telling him to change his clothes in a phone booth and giving him tips on how to impress their new boss. Later she helped Clark investigate a bus crash outside the Planet building and used her own resources to gain information. Together they discovered that Bette Sans Souci was the meteor freak that caused the bus to explode. Soon after, Lois wrote the story, earning herself a front-page headline. When Oliver falls poisoned, Tess told Lois to cover the story on Oliver and put in doubt her professionalism. Lois helped Davis Bloome to cure Oliver and told Davis to do whatever it takes to keep him alive. The situation make Lois wondered if she made the right decision to break up with Oliver and later decided not to do the story about him because of his near death experience and her feelings for him. Lois decided to team up with Clark on a story about a man who died of extremely high hormone levels. She was shocked to find Clark under a spell and making out with a strange redhead woman in the elevator. When Clark sees Lois he is able to break the spell, Clark tries to explain to Lois, who is angry at his behavior. Maxima then tried to kill Lois, and tells Lois that Clark would never have be able to break away from her, if it wasn't for his attraction to Lois. Clark speeds Maxima away just before she hurts Lois. Later, Clark has a discussion about soul mates with Lois, fearing that maybe she is right in front of him and he's too blind to see it, but Lois assures Clark that when he meets the right girl he will know. At Chloe and Jimmy's engagement party, Lois got drunk and felt embarrassed, after making a bad toast about Jimmy and Chloe, ending with hung-over at the Kent Farm. After learning that Chloe and Jimmy never returned home the night before, Lois and Clark then teamed up to find them and she suggested that they pose as an engaged couple to attract the kidnapper. Her plan was successful and she ended up being kidnapped by a psychotic jeweler and was forced to admit her feelings for Clark, in order to save him from electric shock. After Clark saved a clearly embarrassed Lois, she attempted to avoid Clark and claimed she removed the sensor and lied about her feelings. When Jimmy approached Lois about his developing story on a mysterious savior in Metropolis, Lois was skeptical until she was saved by the savior twice after being trapped in the middle of Tess's search for the Crystal of Knowledge. Lois declared that she would find the identity of the hero as well as have the first interview with the world wide hero. Lois decided to take up Clark´s offer to move into the Kent Farm, but they were sucked into the Phantom Zone together due to the Crystal of Knowledge. Clark was able to send Lois back with the help of Kara, however Lois became possessed by Faora, who used Lois' body to locate her son. Clark and Kara vanquish Faora from Lois's body and she thought she had hallucinated the entire experience. After Tess gave her a raise at work, Lois changed her mind about living at the Kent Farm after all. The day of Chloe and Jimmy's wedding, Lois, as the Maid of Honor, was responsible for coordinating the wedding at Clark's farm. When Jimmy suggested Clark might be interested in her, Lois denied they had an attraction. During the wedding, Clark offered Lois a dance and they almost kiss, but were interrupted by Lana Lang's sudden arrival. Lois was upset and disappointed, and later when Chloe's wedding was interrupted by a horrible monster, Lois accompanied a gravely-injured Jimmy Olsen to Star City while he received treatment. She told Clark she would stay there until she heard from Chloe again. Lois stays about a month in Star City with Jimmy. During this time, Chloe mentioned to Clark that she knows that Lois has feelings for him and that Clark shouldn't hurt her. Lois only returns after Lana has already left. When Clark meets Linda Lake, she threatened to tell the world his secret. Clark decided to tell Lois his secret and have her write his story first. Things quickly went from bad to worse. After Clark is wanted by the government, he decided to rewrite time with the Legion ring. Lois is upset because she knows he would not tell her his secret again, Clark reassured her it is because she is special and he wanted to protect her. After Clark rewrites time he picked Lois up from the airport, Lois told him to meet with her to talk about their kiss. Despite Clark showing up he sent her a text message saying he was held up and couldn't make it. Lois clearly disappointed, texted back saying that she couldn't make it there either. On Chloe's birthday, Lois was assigned to go to Mexico, and while there, Chloe became Lois for one day due to a spell. After Lois returned, she questioned Clark on when he realized Chloe wasn't her and wanted to see the framed copies of her rules that Chloe told her about. After Lois realized that her journalistic achievements were not advancing, she assumed that an interview or a story about. a superhero could relaunch her career and decided to invent her own super-heroine Stiletto. When she started to patrol Metropolis in hopes of befriending the Red Blue Blur, Clark discovered and unmasked her and the advised her that she did not need to make up false stories to be a good journalist. After Lois as Stiletto saved Clark and Jimmy, she received a message from the Red Blue Blur asking to finally talk at a phone booth. At night, Lois was excited to talk with her hero and when she finally did, she told him that she wanted be his friend and suggest a new super-hero name for him. Clark told her that when he was ready to tell the world who he really was, she'd be the first to know. Several weeks later, Lois was stubborn in finding Chloe after she disappeared and when the Red Blue Blur contacted her to publish his goodbye letter to the citizens of Metropolis, she requested that they meet each other at least once, by the phone booth at midnight. Lois broke into Tess' office to use her computer but found it encrypted. With Jimmy's help, they tracked Chloe and Davis and when Jimmy left to go get them, Lois continued looking through the computer and unearthed a video in Tess' files of Tess torturing Regan Matthews about an Orb that was alien tech and could potentially destroy all of mankind. When she left Tess' office to go find Chloe, Tess confronted Lois and accused her of stealing the orb from her. Tess stopped her from leaving and attacked her. Lois fought back and in middle of the struggle, Lois found the Legion ring on the floor after knocking over Clark's things and when she picked it up, it was activated and transported her one year into the future.